Monoclonal Antibodies as Therapeutic Agents

Monoclonal Antibodies as Therapeutic Agents What are antibodies? Antibodies are holy person for the consumption in drug therapies because they are very particular in the functions that they carry out in biological sy foots. They substructure be described as Y-shaped proteins that consist of four polypeptide irons. Residing in the accouterments of the Y are two identical light polypeptide bonds and the angry walk of the Y consists of two heavy polypeptide chains. The light polypeptide chains that imprint up the arms are referred to as a fab (Fragment for Antigen Binding) and function by recognising the antibodys target or antigen (antibody generating molecule). The stem of the Y is known as the Fc fortune of the antibody. The stems main graphic symbol is to communicate with the world immune strategy so that it initiates a series of immunilogical responses. These initiated immunilogical responses include ADCC (Antibody Dependent Cellular Cytotoxicity) in which pilot light human immune system cells bind to the Fc via specific antibody dwell song receptors. These immune cells are then signalled to destroy the attack entity, a molecule or a whole cell, to which the antibody is bound. The co-occurrence system is another immune response that can be initiated, where a series of blood proteins bind to the Fc and subsequently give the axe remnant of the invading target.

An important factor in the efficacy of antibody therapeutics is that the Fc portion also provides for the long half-life of the antibody within the blood. The storey of antibody research. In the youthful 1800s scientists discovered that blood serum which! was interpreted from mice that were immunised (exposed to) with human proteins contained a mixture of mouse antibodies that could be used to combat certain diseases. This, however, was problematic in that there was no technology available at the time to bring forth sufficient quantities of... If you loss to get a full essay, launch it on our website: OrderCustomPaper.com

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